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Autoimmune Blood Tests: When Your Body Attacks Itself

By the EllaDx team · Updated November 1, 2026 · 1 min read

For education only, not a diagnosis. Talk to your clinician about your results.

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Women account for 78% of autoimmune disease cases. If you're experiencing unexplained symptoms, autoimmune testing may provide answers.

What Are Autoimmune Diseases?

In autoimmune conditions, your immune system mistakenly attacks your own tissues. There are over 80 types, including:

  • Hashimoto's thyroiditis
  • Rheumatoid arthritis
  • Lupus
  • Celiac disease
  • Multiple sclerosis
  • Type 1 diabetes

Common Autoimmune Symptoms

  • Fatigue
  • Joint pain and swelling
  • Skin problems
  • Digestive issues
  • Recurring fever
  • Swollen glands

Autoimmune Screening Tests

ANA (Antinuclear Antibody)

A screening test for many autoimmune conditions. Positive ANA may not mean disease but may warrant further investigation.

Specific Antibodies

  • Thyroid antibodies (TPO, TgAb) - may point to Hashimoto's
  • RF and anti-CCP - may point to rheumatoid arthritis
  • Anti-dsDNA, Anti-Smith - may point to lupus
  • Anti-tTG, Anti-EMA - may point to celiac disease

Inflammatory Markers

  • CRP (C-reactive protein)
  • ESR (sed rate)
  • Ferritin (can be elevated in inflammation)

Important Notes

  • Autoimmune diseases can cluster
  • Diagnosis can take years
  • Early detection can improve outcomes
  • Lifestyle factors can influence disease activity

References

  • Jacobson, D. L., et al. (1997). Epidemiology and estimated population burden of selected autoimmune diseases in the United States. Clinical Immunology and Immunopathology, 84(3), 223-243. PMID 9281381
  • Fairweather, D., & Rose, N. R. (2004). Women and autoimmune diseases. Emerging Infectious Diseases, 10(11), 2005-2011. PMID 15550215