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Other tests
Aldolase test
Muscle enzyme used to evaluate inflammatory muscle disease like polymyositis and dermatomyositis.
At a glance
In about 5 days
Most results are ready in about 5 days. Some specialty markers can take up to 21 days.
Check before your draw
This marker has no preparation tag, but it can still need preparation. Contact us before your draw if you’re not sure.
Walk in at Quest
Your lab order arrives by email. Most Quest locations take walk-ins, so bring it with a photo ID.
What it measures
Aldolase is an enzyme, a type of protein, found mostly in your muscles. When muscles are inflamed or injured, more of it can leak into your blood.
Why it matters for women
Conditions where the immune system inflames the muscles, such as dermatomyositis and polymyositis, are more common in women. Dermatomyositis can also cause a purple or red rash on the eyelids or knuckles. Aldolase may be read alongside other muscle tests, since hard exercise can raise it too.
You might check it if…
- your muscles feel weak, especially in your hips, thighs or shoulders
- climbing stairs or lifting your arms has gotten harder
- you notice a purple or red rash on your eyelids or knuckles
- a doctor is looking into a muscle condition
What your result may mean
High Aldolase: what it may mean
High aldolase may reflect skeletal muscle damage from polymyositis, dermatomyositis, muscular dystrophy or rhabdomyolysis, a severe breakdown of muscle. Dermatomyositis and polymyositis can be more common in women, and dermatomyositis can also cause a purple or red rash on the eyelids or knuckles. Hard exercise can raise aldolase too, and so can liver injury, so a recent tough workout may sway your result. You may notice muscle weakness or aches, and a clinician may read this test with creatine kinase (CK) and other muscle enzymes.
Low Aldolase: what it may mean
Low aldolase may not be clinically meaningful. This enzyme can stay at small amounts in the blood when muscles are healthy, and it can leak out in larger amounts when muscle cells are inflamed or hurt. A low or normal result can't rule out a muscle condition by itself, since aldolase may stay in range in some people with muscle inflammation. For muscle aches or weakness, a clinician may look at CK and other muscle tests as well.
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These notes provide context and do not diagnose a condition. Not yet available in NY, NJ, RI, HI, ND, SD or WV.