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Autoimmune & inflammation
Cardiolipin antibody (IgG) test
Antiphospholipid antibody; persistently positive results may suggest antiphospholipid syndrome (APS), a clotting disorder.
At a glance
In about 5 days
Most results are ready in about 5 days. Some specialty markers can take up to 21 days.
Check before your draw
This marker has no preparation tag, but it can still need preparation. Contact us before your draw if you’re not sure.
Walk in at Quest
Your lab order arrives by email. Most Quest locations take walk-ins, so bring it with a photo ID.
What it measures
Looks for antibodies that can make your blood more likely to clot. Your immune system sometimes makes them by mistake, and this checks the IgG type, the one that may be most linked to clotting problems.
Why it matters for women
These antibodies can be a common, treatable cause of repeated miscarriage and of some pregnancy problems such as preeclampsia, a high blood pressure problem in pregnancy. They can also raise the risk of clots, especially with estrogen birth control or during pregnancy. Because they can show up briefly after an infection, a positive result may be rechecked a few months later.
You might check it if…
- you’ve had two or more miscarriages
- you’ve had a blood clot, especially at a young age
- you’ve had severe preeclampsia or a pregnancy loss after the early weeks
- a doctor mentioned lupus or another autoimmune condition
What your result may mean
High Cardiolipin antibody (IgG): what it may mean
High cardiolipin IgG may point to antiphospholipid syndrome (APS), a condition that can cause blood clots and pregnancy loss, especially when the antibody stays high on repeat testing. One positive result can't settle it, since infections and some medicines can raise it briefly, so a clinician may recheck it a few months later. Lupus can come with these antibodies too. Some women may have repeated miscarriages or preeclampsia, and a clot can bring a swollen, painful leg. Estrogen birth control and pregnancy can add to clot risk.
Low Cardiolipin antibody (IgG): what it may mean
Low or negative cardiolipin IgG may make antiphospholipid syndrome (APS) less of a concern, and it can't rule APS out on its own. Some people with APS can have other antiphospholipid antibodies instead, so a clinician may look at lupus anticoagulant, beta-2 glycoprotein I and the IgM version of this test. A full set can be useful after a blood clot, repeated miscarriage or stillbirth. Without a history of clots or pregnancy problems, a negative result may need no follow-up.
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These notes provide context and do not diagnose a condition. Not yet available in NY, NJ, RI, HI, ND, SD or WV.