$30.00
Priced per marker, with baseline labs included. You’ll see your total before you pay.
Autoimmune & inflammation
Jo-1 antibody test
Autoantibody specific for antisynthetase syndrome, a subset of inflammatory myositis with lung involvement.
At a glance
In about 5 days
Most results are ready in about 5 days. Some specialty markers can take up to 21 days.
Check before your draw
This marker has no preparation tag, but it can still need preparation. Contact us before your draw if you’re not sure.
Walk in at Quest
Your lab order arrives by email. Most Quest locations take walk-ins, so bring it with a photo ID.
What it measures
Jo-1 is an antibody linked to a rare condition where the immune system inflames the muscles and often the lungs. It can cause muscle weakness, a lasting cough, or shortness of breath.
Why it matters for women
Conditions that inflame the muscles, like this one, affect women more often than men. This one often affects the lungs too, so spotting it early matters. It can also cause joint pain, fingers that turn white in the cold, and rough, cracked skin on the hands.
You might check it if…
- your thigh, hip, or shoulder muscles feel newly weak
- you’ve had a dry cough or breathlessness that lingers
- the skin on your fingers is rough and cracked
- a doctor is looking into muscle inflammation
What your result may mean
High Jo-1 antibody: what it may mean
A positive Jo-1 antibody may point to antisynthetase syndrome, a rare form of inflammatory muscle disease (polymyositis or dermatomyositis) that can also scar the lungs (interstitial lung disease). This antibody can be highly specific for the condition. Muscle weakness, a lasting cough, shortness of breath, joint pain, fingers that turn white in the cold, and rough, cracked skin on the hands can all be part of it. Inflammatory muscle conditions can affect women more than men, so a clinician may add muscle enzyme tests and lung imaging to look closer.
Low Jo-1 antibody: what it may mean
A negative Jo-1 antibody may make antisynthetase syndrome less of a worry, and it can't rule out muscle or lung inflammation on its own. Other antibodies can be found in related conditions, so a clinician may order a wider myositis panel. Muscle weakness can also come from thyroid problems, low vitamin D or some medicines, including statins, which can make muscles ache. A lasting cough or breathlessness may need its own lung checks.
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No insurance required · HSA/FSA eligible · No subscription
These notes provide context and do not diagnose a condition. Not yet available in NY, NJ, RI, HI, ND, SD or WV.